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研究植物源性钙通道阻滞剂粉防己碱（Ｔｅｔ）对大鼠膀胱平滑肌的作用。结果发现，在整体实验中，Ｔｅｔ８ｍｇ／ｋｇ灌胃能在较少影响血压、心率的情况下，降低膀胱平滑肌的收缩力（Ｐ＜０．０１）。在离体实验中，Ｔｅｔ（１０、３０μｍｏｌ／Ｌ）能浓度依赖性地非竞争性抑制由ＫＣｌ引起的大鼠正常和肥厚膀胱平滑肌的收缩反应，ＰＤ２′值分别为４．３５和３．７９。在连续每ｄ灌胃Ｔｅｔ８ｍｇ／ｋｇ６周后，能减轻膀胱重量并改善形态学变化，且明显降低膀胱对外源性激动剂如ＫＣｌ的反应性（Ｐ＜０．０１）。提示Ｔｅｔ在治疗某些泌尿系统疾病如膀胱激惹综合征等有一定的应用前景
To study the effect of plant-derived calcium channel blocker tetrandrine (Tet) on rat bladder smooth muscle. The results showed that in the overall experiment, Tet8mg/kg gavage can reduce the contractility of smooth muscle of the bladder (P<0.01) with less effect on blood pressure and heart rate. In vitro, Tet (10, 30 μmol/L) inhibited the contractile responses of normal and hypertrophic bladder smooth muscle in rats induced by KCl in a concentration-dependent manner, with PD2′ values of 4.35 and 3.79, respectively. . After 6 weeks of continuous intragastric administration of Tet (8mg/kg), the weight of the bladder was reduced and the morphological changes were improved, and the reactivity of the bladder exogenous agonist such as KCl was significantly reduced (P<0.01). Tip Tet has a certain application prospect in the treatment of certain urinary system diseases such as bladder irritation syndrome