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人巨细胞病毒(HCMV)感染在人群中相当普遍,通常呈潜伏感染,外周血单核细胞和骨髓造血祖细胞是HCMV主要潜伏部位,经过细胞分化、免疫抑制、细胞因子作用等潜伏-激活机制可致严重疾病。近10年来,随着免疫低下状态人群(艾滋病,器官移植和恶性肿瘤等患者)的增多,HCMV感染及其引发的严重疾病逐渐增加,造血系统常受累,其中骨髓抑制和血小板减少症常见。
Human cytomegalovirus (HCMV) infection is quite common in the population, usually latent infection, peripheral blood mononuclear cells and bone marrow hematopoietic progenitor cells are the main latent sites of HCMV, after a latent-activation mechanism such as cell differentiation, immunosuppression, cytokines Can cause serious illness. In the past 10 years, with the increase of immunocompromised people (AIDS, organ transplantation and malignant tumors), HCMV infection and its serious diseases are gradually increased, and the hematopoietic system is often involved. Myelosuppression and thrombocytopenia are common.