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目的：为明确增殖细胞核抗原在神经母细胞瘤中的表达及其临床意义。方法：对２０例神经母细胞瘤及对照组５例采用免疫组织化学染色进行回顾性研究。结果：神经母细胞瘤中增殖细胞核抗原（ＰＣＮＡ）及增殖细胞核Ｋｉ－６７抗原（Ｋｉ－６７）阳性者均为２０例，随着临床分期的升高，Ⅲ～Ⅳ级的表达率也明显增高；对照组５例均为阴性。结论：在小儿神经母细胞瘤中，ＰＣＮＡ及Ｋｉ－６７是反应肿瘤细胞活性的敏感指标，对预后判断也有一定价值
Objective: To clarify the expression of proliferating cell nuclear antigen in neuroblastoma and its clinical significance. Methods: Retrospective study was performed on immunohistochemical staining of 20 cases of neuroblastoma and 5 cases of control group. Results: Proliferating cell nuclear antigen (PCNA) and proliferating cell nucleus Ki-67 antigen (Ki-67) positive in neuroblastoma were 20 cases. With the increase of clinical stage, the expression rate of grade III to IV was also significantly increased. The control group was negative in 5 cases. Conclusion: In children with neuroblastoma, PCNA and Ki-67 are sensitive indicators of the activity of tumor cells, and have a certain value for prognosis.