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目的探讨原发性胆汁性肝硬化(PBC)的临床特点、诊断和治疗,以提高临床医生对该病的认识。方法对30例原发性胆汁性肝硬化患者的临床资料、实验室检测、诊断进行分析。结果本组病例皆为女性,确诊时的平均年龄为(58.1±7.8)岁,初诊至确诊的时间平均为5.7年(10月～11年),主要症状包括搔痒、乏力、纳差,主要体征包括黄疸、肝大、脾大、腹水。实验室检查以ALP,高GGT、高胆红素血症、高球胆白血症,存在多种自身抗体阳性,AMA-M2具有确诊价值。结论原发性胆汁性肝硬化主要累及中老年女性,最常见的症状为搔痒、乏力,部分早期患者可无症状,血清碱性磷酸酶及谷氨酰转肽酶水平升高及抗线粒体抗体和(或)线粒体抗体M2亚型阳性有助于诊断本病。
Objective To investigate the clinical features, diagnosis and treatment of primary biliary cirrhosis (PBC) in order to improve clinicians’ understanding of the disease. Methods The clinical data, laboratory tests and diagnosis of 30 patients with primary biliary cirrhosis were analyzed. Results The patients in this group were all female. The mean age at diagnosis was (58.1 ± 7.8) years. The average time from diagnosis to diagnosis was 5.7 years (October to 11 years). The main symptoms included itching, fatigue, anorexia, major signs Including jaundice, liver, spleen, ascites. Laboratory tests with ALP, high GGT, hyperbilirubinemia, hypercholesterolemia, there are many positive autoantibodies, AMA-M2 has a definite value. Conclusions Primary biliary cirrhosis mainly affects middle-aged and old-aged women. The most common symptoms are itchiness and fatigue. Some patients with early symptoms may be asymptomatic, serum alkaline phosphatase and glutamyl transpeptidase levels are elevated, and anti-mitochondrial antibodies and (Or) mitochondrial antibody M2 subtype positive help to diagnose the disease.