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对临床缺血性脑卒中兼有血瘀证患者按不同病期分别进行血浆 t-PA、PAI活性水平检测。结果表明,急性期 t-PA 活性增高,并可持续到临床恢复期,至后遗症期呈下降趋势;急性期 PAI 活性较健康成人低,但在恢复期发生逆转,血浆 PAI 活性升高,至临床后遗症期尤为明显。由于上述改变使 PAI/t-PA 比值在不同病期发生异常变化,后期临床血瘀证候虽有一定改善,但这一血液学异常依然存在,并可能是血栓再度形成的危险因子之一,也是缺血性脑卒中临床复发率较高的原因。
Plasma ischemic stroke patients with both blood stasis according to different stages of plasma t-PA, PAI activity levels were detected. The results showed that t-PA activity increased in acute phase and continued to clinical recovery until the sequelae showed a downward trend; PAI activity in acute phase was lower than that in healthy adults, but reversed in recovery period, plasma PAI activity increased to clinical Sequelae are particularly noticeable. As the above changes make PAI / t-PA ratio abnormal changes in different stages of disease, although the clinical syndrome of blood stasis improved to some extent, but the hematological abnormalities still exist, and may be one of the risk factors for the re-formation of thrombus, Is also a high incidence of clinical recurrence of ischemic stroke causes.