Combining targeted therapy and immune checkpoint inhibitors in the treatment of metastatic melanoma

• 作 者: Teresa Kim Rodabe N. Amaria Ch
• 机 构: DepartmentofSurgery,HarvardMedicalSchool,DepartmentofMelanomaMedicalOncology,~DepartmentofGenomicMed
• 出 处: 癌症生物学与医学：英文版
• 发表日期: 2014年4期
• 关键词: 免疫抑制剂 靶向治疗 检查点 转移性 黑色素瘤 协同作用 免疫疗法 CTLA4 Melanoma checkpoint blockade BRAF inhi
• 基金项目: NIH grants 1K08CA160692-01A1,U54CA163125-01 and the generous philanthropic support of several families whose lives have been affected by melanoma

Melanoma is the deadliest form of skin cancer and has an incidence that is rising faster than any other solid tumor. Metastatic melanoma treatment has considerably progressed in the past five years with the introduction of targeted therapy(BRAF and MEK in