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目的探讨肺结核并发肺部真菌感染的易感因素。方法收集2008年7月—2009年7月皖南医学院附属弋矶山医院收治的522例肺结核临床资料,以并发肺部真菌感染54例为观察组,未并发肺部真菌感染468例为对照组,进行回顾性分析。结果观察组与对照组在性别、年龄、体质量指数、临床类型、是否长期使用广谱抗生素、是否应用糖皮质激素、有无糖尿病、痰涂片抗酸染色情况等指标之间的差异均有统计学意义(P<0.05)。通过多因素非条件Logistic回归分析筛选出老年人、长期使用广谱抗生素或糖皮质激素及合并糖尿病者等为易感的高危因素。结论对于老年人、长期使用广谱抗生素或糖皮质激素及合并糖尿病者更需提高警惕,必要时采取相应的预防监控措施。
Objective To investigate the susceptibility factors of pulmonary fungal infection in pulmonary tuberculosis. Methods The clinical data of 522 cases of pulmonary tuberculosis admitted to Yijishan Hospital affiliated to Wannan Medical College from July 2008 to July 2009 were collected. 54 cases of pulmonary fungal infection were observed, and 468 cases of non-concurrent pulmonary fungal infection were selected as the control group , For retrospective analysis. Results The difference between the observation group and the control group in sex, age, body mass index, clinical type, whether long-term use of broad-spectrum antibiotics, whether glucocorticoid, diabetes, sputum smear acid-fast staining and other indicators Statistical significance (P <0.05). Multivariate non-conditional Logistic regression analysis screened the elderly, long-term use of broad-spectrum antibiotics or glucocorticoid and diabetes were risk factors for susceptibility. Conclusion For the elderly, long-term use of broad-spectrum antibiotics or glucocorticoids and diabetes mellitus need to be more vigilant, if necessary, take appropriate preventive measures.