论文部分内容阅读
４０例ＨＰ阳性的慢性萎缩性胃炎用两种不同方法治疗，观察治疗前后胃粘膜炎症程度，ＨＰ感染情况及粘膜上皮的增殖状态。治疗前，两组胃粘膜炎症均明显，有数量不等的ＨＰ，平均增殖细胞核抗原（ＰＣＮＡ）标记指数（ＬＩ）均较高，组合治疗组为２４．８５±２．７９，硫糖铝组为２４．３１±１．８９。治疗后，组合治疗组炎症明显消退，ＨＰ消失，ＰＣＮＡＬＩ下降（２０．４９±２．５２，Ｐ＜０．００１）。硫糖铝组炎症未消退，ＨＰ持续存在，ＰＣＮＡＬＩ下降不明显（２３．８８±１．０９，Ｐ＞０．１０）。结果提示ＨＰ感染引起胃粘膜活动性炎症时，胃粘膜上皮处于高增殖状态。
Forty cases of HP-positive chronic atrophic gastritis were treated by two different methods. The degree of gastric mucosal inflammation, HP infection and mucosal epithelial proliferation were observed before and after treatment. Before treatment, gastric mucosal inflammation was obvious in both groups, ranging from a high number of HP to a high labeling index of proliferating cell nuclear antigen (PCNA), the combined treatment group was 24.85 ± 2.79, and the sucralfate group 24.31 ± 1.89. After treatment, the combination treatment group subsided significantly, HP disappeared and PCNALI decreased (20.49 ± 2.52, P <0.001). Inflammation of sucralfate group did not subside, HP persisted and PCNALI did not decrease significantly (23.88 ± 1.09, P> 0.10). The results suggest that HP infection caused gastric mucosal active inflammation, gastric mucosal epithelium in a high proliferative state.