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目的:探究应用阿奇霉素序贯疗法治疗小儿支原体肺炎的临床疗效及安全性。方法:选取我院2009年3月～2011年5月收治的217例小儿支原体肺炎患儿为研究对象。将其随机分为两组,其中一组为对照组(109例),对照组患儿应用红霉素序贯疗法进行治疗,另外一组为实验组(108例),实验组患儿应用阿奇霉素序贯疗法进行治疗。治疗结束后,比较两组患儿的治疗总有效率、症状改善时间、住院时间和不良反应发生率。结果:实验组患儿的治疗总有效率明显高于对照组患儿,且组间差异具有显著性(p<0.05);实验组患儿的症状改善时间、住院时间均少于对照组患儿,且组间差异具有显著性(p<0.05);实验组患儿的不良反应发生率低于对照组患儿,且组间差异具有显著性(p<0.05)。结论:应用阿奇霉素序贯疗法治疗小儿支原体肺炎具有疗程短、起效快、效果好、不良反应少等优点,是一种值得在临床上推广和应用的疗法。
Objective: To investigate the clinical efficacy and safety of sequential treatment of azithromycin in children with mycoplasma pneumonia. Methods: A total of 217 children with Mycoplasma pneumoniae pneumonia admitted in our hospital from March 2009 to May 2011 were selected as the study subjects. One group was control group (109 cases), the control group was treated with erythromycin sequential therapy, the other group was experimental group (108 cases), the experimental group was treated with azithromycin Sequential therapy for treatment. After treatment, the total effective rate, symptom improvement time, hospitalization time and incidence of adverse reactions in both groups were compared. Results: The total effective rate of treatment group was significantly higher than that of control group, and there was significant difference between the two groups (p <0.05). The symptom improvement time and hospitalization time of experimental group were less than those of control group (P <0.05). The incidence of adverse reactions in the experimental group was lower than that in the control group, and the difference between the two groups was significant (p <0.05). Conclusion: Sequential azithromycin treatment of children with mycoplasma pneumonia has the advantages of short course of treatment, rapid onset, good effect and few adverse reactions. It is a kind of therapy worthy of promotion and application in clinic.