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止生凝系由家兔脑组织提取,主要成分为卵磷脂、脑磷脂的生化药物,临床试用于血小板减少性出血症,疗效显著。本文探讨了止生凝对实验动物血小板计数和聚集功能的影响。结果表明,止生凝200～400mg/kg ip于0.5小时内可分别升高家兔、大鼠的血小板计数;小鼠灌服止生凝800mg/kg/日,一周后血小板计数明显提高,并能拮抗500rad~(60)Co辐射引起的血小板减少症。家兔i.p止生凝500mg/kg时,能抑制ADP诱发的血小板聚集作用,而止生凝在体外促家兔血小板聚集。止生凝的水溶性成份i.v使小鼠凝血时间显著缩短。
Zhixin condensate from the rabbit brain tissue extract, the main component of lecithin, brain phospholipid biochemical drugs, clinical trial of thrombocytopenia hemorrhagic disease, a significant effect. This article explores the effect of antithrombotic on platelet count and aggregation in experimental animals. The results showed that only 200 ~ 400mg / kg ip could increase the platelet count of rabbits and rats in 0.5 hour respectively. The mice received 800 mg / kg / day of coagulation only after one week, and the platelet counts increased significantly after one week Can antagonize 500rad ~ (60) Co radiation induced thrombocytopenia. Rabbit i.p only coagulation 500mg / kg, can inhibit ADP-induced platelet aggregation, and only coagulation in vitro promote rabbit platelet aggregation. The immiscible water-soluble component i.v significantly shortened clotting time in mice.