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硫代甲基化是许多含巯基药物和毒物代谢的重要途径,例如巯甲丙脯酸和D青霉胺在人体内形成其5甲基衍生物。脂肪族化合物的硫化甲基化是由硫化甲基转移酶(TMT)催化的。TMT是膜结合的酶,这个酶已在实验动物和人体红细胞和肾脏所获得的膜标本上进行了研究。人体红细胞膜能催化许多药物的S甲基化,其中包括巯甲丙脯酸,D和L青霉胺、N乙酰胱氨酸以及安体舒通的巯基代谢物等。红细胞膜就存在
Thiomethylation is an important pathway for many thiol-containing drugs and toxic metabolites. For example, captopril and D penicillamine form their 5-methyl derivatives in humans. Sulfidomethylation of aliphatic compounds is catalyzed by sulphur-methyltransferase (TMT). TMT is a membrane-bound enzyme that has been studied on membrane specimens obtained from experimental animals and from human red blood cells and kidneys. Human erythrocyte membranes can catalyze S methylation of many drugs, including captopril, D and L penicillamine, N-acetylcysteine, and the metabolites of spironolactone and so on. Erythrocyte membrane exists