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目的探讨选择性β_1受体阻滞剂对高血压患者运动耐力的影响。方法 2015年5月至2016年5月,72例高血压患者按照是否服用选择性β_1受体阻滞剂分为两组。A组(n=35)行心肺运动试验前2周服用选择性β_1受体阻滞剂,B组(n=37)行心肺运动试验前2周未曾服用任何β受体阻滞剂。两组均行心肺运动试验,比较两组间运动耐力。结果 A组最大收缩压、峰值心率、运动后1 min时心率(HR1)和最大心率血压乘积均低于B组(t>2.012,P<0.05),而HR1恢复值高于B组(t=2.100,P<0.05)。两组间峰值功率及峰值摄氧量均无显著性差异(t<0.689,P>0.05)。结论选择性β_1受体阻滞剂可降低心肌耗氧量,改善迷走神经张力,并未降低高血压患者的运动耐力。
Objective To investigate the effect of selective beta-1 blockers on exercise tolerance in hypertensive patients. Methods From May 2015 to May 2016, 72 patients with hypertension were divided into two groups according to whether they took selective beta-1 blockers. Patients in group A (n = 35) underwent selective β 1 blockers 2 weeks prior to cardiopulmonary exercise test and group B (n = 37) did not receive any β blockers 2 weeks prior to cardiopulmonary exercise test. Cardiopulmonary exercise tests were performed in both groups, and exercise endurance was compared between the two groups. Results The maximum systolic blood pressure, peak heart rate, product of heart rate (HR1) and maximum heart rate at 1 min after exercise in group A were lower than those in group B (t> 2.012, P <0.05) 2.100, P <0.05). There was no significant difference in peak power and peak oxygen uptake between the two groups (t <0.689, P> 0.05). Conclusion Selective β - 1 blockers can reduce myocardial oxygen consumption, improve vagal tone, did not reduce exercise tolerance in patients with hypertension.