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目的 :应用磁共振 (MRI)测定颞叶癫痫 (TL E)患者 ,非 TL E患者及正常人的海马结构(HF)体积。讨论该方法在确定 TL E致痫灶中的价值。方法 :用 MRI对 1 3例 TL E患者 ,1 7例非TL E患者及 37例正常人作与脑干长轴平行的倾斜冠状位扫描 ,SE序列 T1加权像 ,测量 HF的体积。采用正常人 HF体积的正常范围及左右两侧 HF体积的差值的正常范围对 TL E患者可能存在的海马硬化进行定位定侧。结果 :正常人 HF的体积范围 :右侧为 1 .95～ 3.6 8cm3,左侧为 1 .93～3.6 1 cm3。TL E组有 7例患者的 HF体积缩小 ,其中 2例为双侧萎缩 ,而非 TL E组无一例 HF体积缩小。结论 :利用 MRI定量测定 HF技术对 TL E患者可能存在的海马萎缩 (HA)的定位定侧有较高的敏感性 ,比目测读片敏感 ,能提高 TL E患者 HA的检出率。
Objective: To determine the hippocampal formation (HF) volume of patients with temporal lobe epilepsy (TL E), non-TL E patients and normal subjects by using magnetic resonance imaging (MRI). Discuss the value of this method in the determination of epileptogenic lesions of TL E. Methods: Thoracic coronal scan parallel to the long axis of brain stem was performed on 13 patients with TL E, 17 non-TL E patients and 37 normal controls by MRI. The volume of HF was measured by SE sequence weighted imaging. The normal range of normal HF volume and the normal range of HF volume difference between left and right sides were used to locate and locate the possible hippocampal sclerosis in TLE patients. Results: Normal human HF volume range: the right side of 1.95 ~ 3.6 8cm3, the left side of 1.93 ~ 3.6 1 cm3. In the TL E group, 7 patients had a decrease in HF volume, with bilateral atrophy in 2 patients and no HF volume reduction in non-TL E patients. CONCLUSION: The quantitative determination of HA by MRI is sensitive to the localization of possible hippocampal formation (TL) in patients with TLE, which is more sensitive than the visual reading and can improve the detection rate of HA in patients with TLE.