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目的探讨微创手术对直肠癌患者免疫功能的影响。方法按照随机分配原则将100例患者平均分成两组。实验组行腹腔镜手术治疗,对照组行开腹手术治疗。结果实验组术中出血量、胃肠道恢复时间、术后住院时间均优于对照组,两组比较差异有统计学意义(P<0.05);对照组手术时间少于实验组,差异有统计学意义(P<0.05);两组患者术后1、3、5 d C-反应蛋白和白细胞介素-6均增高,差异有统计学意义(P<0.05);两组患者术后1、3、5 d CD3~+、CD4~+、CD8~+和CD4~+/CD8~+水平比较差异有统计学意义(P<0.05)。结论腹腔镜手术对直肠癌患者免疫功能的影响小,值得在临床上推广使用。
Objective To investigate the effect of minimally invasive surgery on immune function in patients with rectal cancer. Methods According to the principle of random allocation of 100 patients were divided into two groups. The experimental group underwent laparoscopic surgery, while the control group underwent open surgery. Results The blood loss, gastrointestinal tract recovery time and postoperative hospital stay in the experimental group were all better than those in the control group, with significant difference between the two groups (P <0.05). The operation time of the control group was less than that of the experimental group (P <0.05). The levels of C-reactive protein and interleukin-6 in the two groups were significantly increased at 1, 3 and 5 days postoperatively (P <0.05) The levels of CD3 ~ +, CD4 ~ +, CD8 ~ + and CD4 ~ + / CD8 ~ + on day 3,5 were significantly different (P <0.05). Conclusion Laparoscopic surgery on immune function in patients with small rectal cancer, it is worth promoting in clinical use.