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目的:探讨白细胞介素1受体1(IL-1R1)在海马区的表达与癫(疒间)发病的关系。方法:用免疫细胞化学法,观察成年和美解眠致(疒间)大鼠海马区IL-1R1免疫反应(IL-1R1-IR)阳性细胞分布。结果:成年大鼠海马区存在IL-1R1-IR阳性细胞。美解眠致(疒间)后,海马区该阳性细胞数显著增多(P＜0.01);致(疒间)前后给予尼莫地平,海马区该阳性细胞均较癫(疒间)大鼠显著减少(P＜0.01),与正常比较无显著差异(P＞0.05)。结论:海马区IL-1R1参与癫(疒间)的病理过程,其机制可能与其介导该区细胞内信号传导有关。尼莫地平不仅可以阻止癫(疒间)发作,而且可以减轻其继发的脑损伤。
Objective: To investigate the relationship between the expression of interleukin-1 receptor 1 (IL-1R1) in the hippocampus and the onset of epileptogenesis. Methods: The immunocytochemical method was used to observe the distribution of IL-1R1-immunoreactive (IL-1R1-IR) positive cells in the hippocampus of adult and rats in the United States. Results: There were IL-1R1-IR positive cells in hippocampus of adult rats. The number of positive cells in the hippocampus was significantly increased after the mice were exposed (P <0.01), and the positive cells in nimodipine and hippocampus before and after intercostal administration were significantly higher than those in the epileptic rats Reduced (P <0.01), no significant difference compared with the normal (P> 0.05). CONCLUSION: IL-1R1 is involved in the pathological process of epileptogenesis in the hippocampus, and its mechanism may be related to the intracellular signal transduction mediated by it. Nimodipine can not only prevent the epileptic (inter) seizures, and can reduce its secondary brain damage.