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目的：观察高压氧（ＨＢＯ）对肝硬变患者肝储备功能的影响。方法：将３８例肝硬变患者按肝功能Ｐｕｇｈ等分级方法［１］分为肝功能良好组（ｎ＝１８）和损害组（ｎ＝２０）。于ＨＢＯ治疗前及治疗后６、１２天进行口服葡萄糖耐量试验（计算服糖后１２０、６０分钟血糖浓度比值即ＯＧＴＴＲ１２０／６０），检测血清前白蛋白（ＰＡ）、白／球蛋白比值（Ａ／Ｇ）、总胆红素（ＴＢｉ）、凝血酶原时间（ＰＴ）及靛青绿１５分钟潴留率（ＩＣＧＲ１５），根据以上检查结果判断ＨＢＯ治疗对肝储备功能的影响。结果：ＨＢＯ可明显提高Ａ／Ｇ值及ＰＡ水平，降低ＯＧＴＴＲ１２０／６０、ＴＢｉ及ＩＣＧＲ１５，对ＰＴ亦有明显改善及控制作用。结论：ＨＢＯ可提高肝硬变患者肝储备功能，是肝硬变患者术前准备的有助方法
Objective: To observe the effect of hyperbaric oxygen (HBO) on liver reserve in patients with cirrhosis. Methods: Thirty-eight patients with cirrhosis were divided into hepatic function group (n = 18) and injury group (n = 20) according to liver function Pugh classification [1]. Oral glucose tolerance test was performed before HBO treatment and 6 and 12 days after treatment (the blood glucose concentration ratio was 120 and 60 minutes after oral administration of sugar was calculated as OGTTR120 / 60), serum prealbumin (PA) and white / globulin ratio (A / G), total bilirubin (TBi), prothrombin time (PT) and indigo green 15-minute retention rate (ICGR15), according to the above test results to determine the impact of HBO treatment on liver reserve function. Results: HBO increased A / G and PA levels, decreased OGTTR120 / 60, TBi and ICGR15, but also significantly improved and controlled PT. Conclusion: HBO can improve hepatic reserve in cirrhotic patients and is helpful for the preoperative preparation of cirrhotic patients