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采用ElisA双夹心法和ElisA竞争抑制法测定肝癌高发区61例HBsAg阳性PHC病人和33例HBsAg无症状携带者血清抗-HBc与IgG抗-HBc。结果显示:HBsAg阳性的PHC病人血清单一IgM抗-HBc的检出率(3.3％)显著低于HBsAg无症状携带者(27.3％),而单一IgG抗-HBc的检出率(50.8％)则高于HBsAg无症状携带者(27.3％);两组研究对象血清中既有IgM抗-HBc又有IgG抗-HB啪检出率无显著差别。提示HBV感染先于PHC发生的可能性是存在的。
ElisA double-sandwich method and ElisA competitive inhibition method were used to determine the serum anti-HBc and IgG anti-HBc in 61 HBsAg positive PHC patients and 33 HBsAg asymptomatic carriers. The results showed that the detection rate of single IgM anti-HBc in HBsAg-positive PHC patients was significantly lower than that of HBsAg asymptomatic carriers (27.3%), while the detection rate of single IgG anti-HBc (50.8%) was significantly Higher than that of HBsAg-asymptomatic carriers (27.3%). There was no significant difference in the detection rate of IgM anti-HBc and IgG anti-HBs between the two groups. There is a possibility that HBV infection precedes PHC.