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随着糖尿病发病率的升高,糖尿病相关并发症的发生也逐渐引起研究者的重视.长期高血糖对人体细胞和组织存在毒性作用,在眼部主要影响角膜和视网膜组织.自从发现糖尿病患者玻璃体切割术后发生角膜上皮病变以来,临床医生开始关注糖尿病性角膜病变,发现高血糖通过改变角膜形态、代谢和生理影响角膜各层次结构,包括角膜上皮、角膜神经、泪膜、内皮细胞等,造成不同程度的损害,这些结构的异常改变统称为糖尿病性角膜病变.本文主要对糖尿病角膜病变的发病机制、临床表现和治疗进展进行综述.“,”With the increase of diabetes mellitus,the incidence of diabetic complications has gradually attracted the attention of researchers.Long-term hyperglycemia has toxic effects on cells and tissues in the body,and its most profound effects on eye tissue are the cornea and retina.Clinicians begin to focus on diabetic keratopathy since the occurrence of corneal epithelial lesions after vitrectomy in diabetic patients,and find that hyperglycemia causes damage of different degrees to each layer of the corneal structure by changing the corneal morphology,metabolism and physiology,including corneal epithelium,corneal nerves,tear film and endothelium.Diabetes mellitus results in clinical abnormalities that are referred to as diabetic keratopathy.This review mainly focused on the pathogenesis,clinical features and treatment of diabetic keratopathy.