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目的评估血清肌钙蛋白Ⅰ(CTnI)在检测轮状病毒肠炎患儿心肌损害的价值。方法选择2007年1月—2010年1月我院入院的急性腹泻患儿244例,随机分为轮状病毒肠炎组124例(实验组)及非轮状病毒肠炎组120例(对照组),所有患儿入院后立即抽取静脉血测定CTnI及肌酸激酶同工酶(CK-MB),实验组患儿于入院7d、14d再次抽血复查CTnI及CK-MB。结果轮状病毒肠炎组患儿CTnI及CK-MB阳性率均高于对照组,差异有统计学意义(P<0.001),轮状病毒肠炎组患儿CTnI及CK-MB阳性率分别为62.1%、40.3%,CTnI的阳性率高于CK-MB,差异有统计学意义(P<0.005),实验组患儿于病程3d内、病程7d及14dCTnI阳性率均高于CK-MB。结论 CTnI在判断轮状病毒性肠炎患儿心肌损伤中敏感性,特异性均高于CK-MB,而且其诊断时间窗长,值得在临床推广。
Objective To evaluate the value of serum troponin Ⅰ (CTnI) in the detection of myocardial damage in children with rotavirus enteritis. Methods 244 cases of acute diarrhea hospitalized in our hospital from January 2007 to January 2010 were randomly divided into rotavirus enteritis group 124 cases (experimental group) and non-rotavirus enteritis group 120 cases (control group) All children were admitted to hospital immediately after venous blood samples were collected for determination of CTnI and creatine kinase (CK-MB). Children in the experimental group were reexamined for CTnI and CK-MB on day 7 and 14 after hospital admission. Results The positive rates of CTnI and CK-MB in children with rotavirus enteritis were significantly higher than those in control group (P <0.001). The positive rates of CTnI and CK-MB in children with rotavirus enteritis were 62.1% , 40.3%. The positive rate of CTnI was higher than that of CK-MB (P <0.005). The positive rate of CTnI in the experimental group was higher than that of CK-MB in the course of 3d and the duration of 7d and 14d. Conclusions CTnI is more sensitive and specific in judging the myocardial injury of children with rotavirus enteritis than CK-MB, and its diagnostic time is long and worthy of clinical application.