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［摘 要］目的 了解昆明小白鼠自发性肺肿瘤的发生率、大体形态、组织学类型及生物学特性。方法 共解剖本所繁殖的封闭群小鼠1000只，从各肺叶、气管、肺门淋巴结、心、肝、脾和脑等部位取材固定，常规病理切片，并进行组织病理学检查。结果 剖检发现，肺部有肿物的56只，确诊为肺肿瘤的35只，其余21只为非肿瘤性病变或转移瘤。自发性原发性肺肿瘤的发生率为3．5％。肿瘤的大体形态多数为圆球形结节状，少数为卵圆形、蕈形、扁圆形、巨块形或略方形。32只为肺腺癌，3只为良性乳头状腺瘤。在32只患肺腺癌小鼠中，乳头状腺癌占多数，腺泡型腺癌及混合癌居中，粘液乳头状腺癌最少。在肺肿瘤小鼠中，雄性20只，雌性15只，性别比为4∶3。10～14月龄和生育8～12胎次的小鼠肿瘤发生率明显上升。结论 小鼠自发性肺肿瘤发生率无明显性别差异，随鼠龄增加而上升。小鼠生育胎次不宜超过7胎。
[Abstract] Objective To investigate the incidence, gross morphology, histological type and biological characteristics of spontaneous lung tumors in Kunming mice. Methods A total of 1000 closed mice were dissected from the lungs, trachea, hilar lymph nodes, heart, liver, spleen and brain and other parts of the fixed, routine pathology, and histopathological examination. Results of the autopsy found that there were 56 lung masses, 35 were diagnosed with lung tumors, and the remaining 21 were non-neoplastic lesions or metastases. The incidence of spontaneous primary lung cancer was 3.5%. Most of the general morphology of tumors spherical spherical nodular, a few oval, mushroom-shaped, oblate, massive or slightly square. 32 for lung adenocarcinoma, 3 for benign papillary adenoma. In 32 lung adenocarcinoma mice, papillary adenocarcinoma accounted for the majority of acinar adenocarcinoma and mixed cancer, mucinous papillary adenocarcinoma at least. In lung tumor mice, there were 20 males and 15 females, with a sex ratio of 4: 3. The incidence of tumors was significantly increased in mice aged 10 to 14 months and births of 8 to 12 births. Conclusions The incidence of spontaneous lung tumors in mice showed no significant gender differences and increased with the increase of the age of mice. Mouse birth parity should not exceed 7 tires.