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1976年云南大理血防所发现青蒿素有抗动物血吸虫病的作用。1977年我们用云南药物所供给的青蒿素油剂注射液治疗动物血吸虫病,也证实它有杀虫作用。1977～1979年,我们先后与中国科学院药物研究所、桂林制药厂协作,对一些青蒿素衍生物作筛选试验,发现对小鼠血吸虫均有不同程度的作用,结果见下面附表。其后又从中选用了 Sm224、887和804等进行了动物实验治疗,证明 Sm224和887对病鼠的疗效相似,而887对病兔的疗效较对病鼠的为高,应用不
The discovery of artemisinin in 1976 by anti-schistosomiasis control in Dali, Yunnan Province has anti-schistosomiasis effect. In 1977, we used artemisinin oil injection provided by Yunnan Medicine to treat animal schistosomiasis and confirmed its insecticidal effect. From 1977 to 1979, we cooperated with Institute of Materia Medica, Chinese Academy of Sciences and Guilin Pharmaceutical Factory successively to screen some artemisinin derivatives and found that they all have different degrees of effect on mice Schistosoma. The results are shown in the following table. Subsequently, Sm224, 887 and 804 were selected for animal experiments, which proved that Sm224 and 887 had similar curative effect on the diseased mice, while 887 had a higher curative effect than the diseased mice