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目的:探讨孕中期产前筛查在临床中的应用和意义。方法:以2012年5月~2013年12月在邢台市产前筛查中心进行产前筛查的孕中期孕妇为研究对象,应用TALENT-Ⅱ型时间分辨免疫荧光仪,对孕中期孕妇血清标本进行产妇血清甲胎蛋白(MSAFP)、游离β亚基促绒毛膜(Free-β-hCG)、游离雌三醇(uE3)定量检测,结合孕妇年龄、孕周、体重、有无糖尿病及吸烟史等因素计算风险值,对高风险孕妇跟踪随访妊娠结局。结果:在9 866例参加筛查的孕妇中,共检出高危孕妇924例,高风险率为9.37%;唐氏综合征高风险者663例,高风险率为6.72%;18-三体综合征高风险者286例,高风险率为2.90%;开放性神经管畸形(ONTD)高风险者58例,高风险率为0.59%。经产前诊断确诊12例,均为唐氏综合征。结论:孕中期产前筛查是一种无创伤性检测手段,可有效降低出生缺陷的发生。
Objective: To explore the application of prenatal screening in the second trimester and its clinical significance. Methods: The pregnant women at the second trimester of pregnancy who were prenatal screening in Xingtai Prenatal Screening Center from May 2012 to December 2013 were enrolled in this study. TALENT-Ⅱ time-resolved immunofluorescence was used to detect the serum levels of the second trimester pregnant women Serum a-fetoprotein (MSAFP), Free-β-hCG and uE3 were detected quantitatively and combined with age, gestational age, body weight, diabetes mellitus and smoking history And other factors to calculate the risk value, follow-up of high-risk pregnant women pregnant outcome. RESULTS: Among 9 866 pregnant women who participated in the screening, 924 high-risk pregnant women were detected, the high-risk rate was 9.37%; 663 high-risk patients with Down’s syndrome, the high-risk rate was 6.72%; 18-trisomy synthesis 286 cases were at high risk, the high-risk rate was 2.90%; 58 cases were at high risk of open neural tube defects (ONTD), the high-risk rate was 0.59%. Prenatal diagnosis confirmed 12 cases, are Down Syndrome. Conclusion: The prenatal screening during the second trimester is a noninvasive detection method that can effectively reduce the incidence of birth defects.