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[背景]持久性有机污染物(POPs)是发育毒物,但母亲和父亲均受到POPs暴露对其后代出生大小的影响尚不清楚。[目的]探讨母亲和父亲63种POPs(其中包括五大类污染物)的血清浓度与其后代出生大小测量值之间的关联。[方法]测定234对夫妇在受孕前血清中的9种有机氯杀虫剂、1种多溴联苯(PBB)、7种全氟烷基化学物(PFCs)、10种多溴联苯醚(PBDEs)和36种多氯联苯(PCBs)的浓度。采用多元线性回归估计化学物浓度的自然对数转换(ln转换)值每增加1 SD,所导致的出生体重、身长、头围和婴儿重量指数的差异。对每一对父母单独进行模型估计,调整母亲的年龄、孕前体质指数(kg/m2)等其他混杂因素,并且所有的模型都包含婴儿性别与各种化学品的交互作用项。[结果]女童(n=117)出生体重显著较低(范围为84~195 g)与母亲血清DDT、PBDE-28、PBDE-183浓度的ln转换值增加每增加1 SD、以及父亲血清PBDE-183和PCB-167浓度的ln转换值每增加1 SD相关联。男童(n=113)出生体重较低(范围为98~170 g)与母亲(PCBs 138、153、167、170、195、209和全氟辛基磺酰)和父亲(PCB-172和PCB-195)的POPs血清浓度具有统计学意义的关联,而父亲血清中PBDE-66和PBDE-99浓度均与较高的出生体重相关联。后代头围、身长和婴儿重量指数的差异也与父母的POPs暴露相关联。[结论]受孕前母亲和父亲血清中某些POPs的浓度与后代出生大小差异之间的关联具有统计学意义。
[Background] Persistent organic pollutants (POPs) are developmental toxicants, but the impact of exposure of POPs to mothers and fathers on the size of their offspring is unclear. [Objective] To explore the correlation between the serum concentrations of 63 kinds of POPs (including five kinds of pollutants) in mother and father and the measurement of the size of their offspring. [Method] A total of 9 kinds of organochlorine pesticides, 1 PBB, 7 perfluoroalkyl chemicals (PFCs), 10 PBDEs and 36 kinds of polybrominated diphenyl ethers (PBDEs) Polychlorinated biphenyls (PCBs) concentration. Multiple linear regression was used to estimate the difference in birth weight, length, head circumference, and infant weight index for each 1 SD increase in the log-chemical (ln-converted) value of the chemical concentration. Separate estimates of each pair of parents, adjustment of mother’s age, pre-congenital body mass index (kg / m2) and other confounding factors are included, and all models include an explanation of the interaction of infant sex with various chemicals. [Results] For girls (n = 117), the birth weight was significantly lower (ranged from 84 to 195 g) and the ln conversion of maternal serum DDT, PBDE-28 and PBDE-183 was increased by 1 SD every day, 183 and PCB-167 concentration ln conversion value for each additional 1 SD associated. Boys (n = 113) had lower birth weight (range, 98-170 g) with mothers (PCBs 138, 153, 167, 170, 195, 209 and PFOS) and fathers (PCB-172 and PCB -195) with a statistically significant association, whereas both father’s serum PBDE-66 and PBDE-99 concentrations were associated with higher birth weights. Differences in offspring head circumference, length, and infant weight index are also associated with parental POPs exposure. [Conclusion] The correlation between the concentrations of some POPs in the serum of the mother and father before conception and the size of the offspring was statistically significant.