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木研究对３４例反复自然流产（ＲＳＡ）、１０例１次流产及３８例正常妊娠人流绒毛组织，应用生物化学及免疫组化方法，检测绒毛组织中谷胱甘肽硫转移酶（ＧＳＴ）活性、腺苷脱氨酶（ＡＤＡ）活性和还原型谷胱甘肽（ＧＳＨ）含量及γ谷氨酸转肽酶（γ－ＧＴ）免疫组化定位进行对比性研究。结果表明，ＲＳＡ绒毛组织较正常绒毛组织中ＧＳＴ活性和ＡＤＡ活性均有明显改变（Ｐ＜０．０１）。γ－ＧＴ免疫组化定位、阳性颗粒的分布及强度也有明显的差别。自然流产３次以上较２次和１次流产的ＧＳＨ含量和ＧＳＴ活性明显降低，经统计学分析均有非常显著差别（Ｐ＜０．０１）。该结果提示绒毛组织本身某些生化功能的改变，可能是原因不明的ＲＳＡ的原因之一。
Wood study 34 cases of recurrent spontaneous abortion (RSA), 10 cases of first abortion and 38 cases of normal pregnancy human hair chorion tissue biochemical and immunohistochemical methods to detect villus tissue glutathione S-transferase (GST) activity, Adenosine deaminase (ADA) activity and reduced glutathione (GSH) content and γ-glutamyl transpeptidase (γ-GT) immunohistochemical localization of comparative study. The results showed that RSA villi tissue than the normal villus tissue GST activity and ADA activity were significantly changed (P <0.01). γ-GT immunohistochemical localization, the distribution and intensity of positive particles are also significantly different. The GSH content and GST activity of spontaneous abortion more than three times than those of second and first miscarriage were significantly decreased, and there was a significant difference (P <0.01) by statistical analysis. This result suggests that some changes in biochemical function of villus tissue itself may be one of the reasons for RSA of unknown cause.