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随着检测技术的发展,对乙型肝炎血清学标志(HBVM)临床意义的认识正在逐渐深入和不断更新。高度敏感和特异的聚合酶链反应(PCR)用于检测血清和其它临床标本中HBVDNA,使对HBVM临床意义有了新的认识。人群中存在HBsAg阴性的HBV携带者,相当数量HBsAg阴性的慢性肝病患者为HBV感染所致;抗-HBs出现后仍可有HBV复制;单项抗-HBc阳性者中确有部分为HBV低水平携带;单用HBeAg和抗-HBe作为HBV复制和传染性指标是不可靠的。
With the development of detection technology, the clinical significance of hepatitis B serological markers (HBVM) is gradually deepening and constantly updated. Highly sensitive and specific polymerase chain reaction (PCR) for the detection of HBVDNA in serum and other clinical specimens has brought new insights into the clinical significance of HBVM. HBsAg-negative HBV carriers exist in the population, and a significant number of HBsAg-negative patients with chronic liver disease are caused by HBV infection; HBV replication may still occur after the anti-HBs appear; some of the anti-HBc-positive individuals do have low HBV carriers ; Use of HBeAg and anti-HBe alone as HBV replication and infectious markers is not reliable.