动脉注入α-肿瘤坏死因子治疗恶性胶质细胞瘤的临床效果

• 作 者: 李书权
• 出 处: 国外医学(肿瘤学分册)
• 发表日期: 1993年01期
• 关键词: 恶性胶质细胞瘤 肿瘤坏死因子 星形细胞瘤 胶质母细胞瘤 正常脑组织 实体肿瘤 间变 用药 局部高 瘤周水肿

胶质母细胞瘤和间变的星形细胞瘤因进行性浸润正常脑组织及相对抗常规放疗和化疗,故预后不良.至今尚无令人满意的疗法.近年已用α-肿瘤坏死因子(TNF-α)治疗晚期实体肿瘤.一般静脉用药不甚理想,反应率仅5%,但直接肿瘤内给药疗效却可超过20%.这提示,若使TNF-α疗效高,副作用低,必须局部高浓度用药.作者根据恶性胶质细胞瘤的两大特点(一是颅外转移罕见,无必要全身用药;

Glioblastoma and anaplastic astrocytoma due to progressive infiltration of normal brain tissue and the relative anti-conventional radiotherapy and chemotherapy, so the prognosis is poor .There is no satisfactory treatment.In recent years, has been used a-tumor necrosis factor TNF-α) for the treatment of advanced solid tumors .Vaginal intravenous drug application is not ideal, the response rate of only 5%, but the efficacy of direct intratumoral administration can be more than 20% .This suggests that, if the TNF-α efficacy, low side effects, must Local high concentration medication. According to the two characteristics of glioblastoma (one is extracranial metastasis rare, no need for systemic medication;