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[目的]探讨蛛网膜下腔出血血清与脑脊液NO、CGRP、脑微区血流量及CRP变化规律。[方法]选取2008年1月～2010年1月进行治疗的20例蛛网膜下腔出血患者为观察组,同时选取20名健康人为对照组,后将两组人员的血清与脑脊液NO、CGRP、脑微区血流量及CRP水平进行研究及比较。[结果]经研究及比较发现,观察组的血清与脑脊液NO、CGRP低于对照组,而血清与脑脊液CRP水平高于对照组,脑微区血流量低于对照组,两组比较,P均﹤0.05,差异均有统计学意义。[结论]蛛网膜下腔出血血清与脑脊液NO、CGRP、脑微区血流量及CRP水平变化对于了解其预后及转归有一定的作用,值得临床进一步研究探讨。
[Objective] To investigate the changes of NO, CGRP, cerebral micro-area blood flow and CRP in serum and cerebrospinal fluid of patients with subarachnoid hemorrhage. [Methods] Twenty patients with subarachnoid hemorrhage who were treated from January 2008 to January 2010 were selected as observation group and 20 healthy persons as control group. The levels of serum and cerebrospinal fluid NO, CGRP, Brain micro-area blood flow and CRP levels were studied and compared. [Results] The results showed that the levels of NO and CGRP in serum and cerebrospinal fluid of the observation group were lower than those in the control group, while the levels of CRP in serum and cerebrospinal fluid were higher in the observation group than in the control group. The blood flow in the cerebral micro-area was lower than that in the control group. <0.05, the differences were statistically significant. [Conclusion] The changes of NO, CGRP, cerebral blood flow and CRP levels in the serum and cerebrospinal fluid of patients with subarachnoid hemorrhage play a certain role in understanding the prognosis and outcome of the subarachnoid hemorrhage. It deserves to be further studied clinically.