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目的:评价1剂次流行性腮腺炎减毒活疫苗流行病学保护效果,为优化含流行性腮腺炎疫苗免疫程序提供依据。方法:电子检索《中国期刊全文数据库》和《美国国家医学图书馆数据库》,采用Meta分析对1998年以来发表的1剂次流行性腮腺炎减毒活疫苗保护效果病例对照研究的文献进行汇总、归纳和统计分析。使用RevMan5.3软件进行统计分析。结果:共纳入23篇文献。流行性腮腺炎减毒活疫苗总保护效果为67%(95%CI:59%~73%),不同年龄组含流行性腮腺炎疫苗保护效果差异无统计学意义(χ~2=0.00,P=1.00),不同种类含流行性腮腺炎疫苗保护效果差异无统计学意义(χ~2=0.39,P=0.53)。结论:1剂次含流行性腮腺炎疫苗具有一定的保护效果,但不能阻断流行性腮腺炎流行。
OBJECTIVE: To evaluate the epidemiological protection effect of live attenuated mumps vaccine in one dose and provide the basis for optimizing the immunization schedule with mumps vaccine. Methods: The Chinese Journal Full-text Database and the National Library of Medicine Database were electronically searched. Meta-analysis was used to summarize the case-control studies on the protective effect of live attenuated vaccine against mumps (mumps) Induction and statistical analysis. RevMan5.3 software for statistical analysis. Results: A total of 23 articles were included. The total protective effect of live attenuated mumps vaccine was 67% (95% CI: 59% -73%). There was no significant difference in the protective effect of mumps vaccine in different age groups (χ ~ 2 = 0.00, P = 1.00). There was no significant difference in protective effect between different types of mumps vaccine (χ ~ 2 = 0.39, P = 0.53). Conclusion: 1 dose of mumps vaccine has certain protective effect, but can not block the epidemic of mumps.