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1973年,Feinestone 等用Krugman 的MS-1株做人体实验,用免疫电镜检查,在粪便中发现有病毒样颗粒,其后确认为甲型肝炎病毒颗粒。自此甲型肝炎的诊断有了进展,在日本明确了散发病例的诊断,在和歌山、弘前等地发现了集团流行,了解了甲型肝炎的临床过程。国外已分离到甲型肝炎三株病毒,即Prousl 用狨的肝脏及血清分离的CR—326病毒株;Krugman 的MS—1型病毒株,Deinhnrdt
In 1973, Feinestone et al. Used Krugman’s MS-1 strain to perform human experiments. Immuno-electron microscopy was used to examine the presence of virus-like particles in the feces, which were subsequently confirmed as Hepatitis A virus particles. Since then, there has been progress in the diagnosis of hepatitis A, and the diagnosis of sporadic cases has been clarified in Japan. The group epidemic was discovered in Wakayama and Hirosaki, and the clinical course of hepatitis A was known. Three strains of hepatitis A virus have been isolated from abroad, that is, CR-326 strain isolated from the liver and serum of Prousl by 狨; MS-1 strain of Krugman, Deinhnrdt