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众所周知,洋地黄和血管扩张剂均可改善充血性心力衰竭患者心功能,然而关于这两类药物相对效果的资料缺如。作者比较静脉注射地高辛和/或肼苯哒嗪,对于14例临床代偿的慢性左心衰竭男性患者静坐位和亚极量(25W负荷,50rpm)坐位蹬车运动中即时血流动力学效应。本组包括8例心肌病和6例缺血性心脏病,平均年龄59(45～74)岁,均为窦性心律且血压正常,左心衰竭症状平均有26(3～84)个月,部份患者伴有右心衰竭。试验前停用洋地黄和血管扩张剂至少2周,停用其它药物至少5～7天.试验前一天傍晚将气囊三腔热稀释导管插入肺动脉,并将短塑料管插入桡动脉。给药前依次测定静坐位(14例)和运动(开始后5～10分钟)中(9例)血流动力学参数作为基础值。首日经导管于30秒内将肼苯达嗪0.15mg/kg注入右房,30分钟后测定肼苯达嗪的效应。次日于1小时内静脉注入地高辛
It is well-known that digitalis and vasodilators can improve cardiac function in patients with congestive heart failure, but the lack of information on the relative effects of these two drugs. The authors compared intravenous digoxigenin and / or hydralazine for 14 patients with clinically compensated chronic left heart failure in male patients sitting and sub-polar (25W load, 50rpm) sitting pedal motion in real-time hemodynamics effect. This group includes 8 cases of cardiomyopathy and 6 cases of ischemic heart disease, the average age of 59 (45 to 74) years of age, were sinus rhythm and normal blood pressure, symptoms of left heart failure a mean of 26 (3 to 84) months, Some patients with right heart failure. Before the test, disable digitalis and vasodilators for at least 2 weeks and discontinue other medications for at least 5 to 7 days. In the early evening of the test, insert the balloon three-chamber thermodilution catheter into the pulmonary artery and the short plastic tube into the radial artery. Prior to dosing, hemodynamic parameters were measured as the baseline values for sitting (14) and exercising (5 to 10 minutes after starting) (n = 9). The first day of the catheter in 30 seconds hydralazine 0.15mg / kg into the right atrium, 30 minutes after the determination of hydralazide effect. The next day intravenous injection of digoxin in 1 hour