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目的观察消化性溃疡患者在根除HP(幽门螺杆菌)后对胃食管反流的影响。方法观察86例患者,以快速尿素酶法1、3C呼气试验诊断HP感染。予经典三联疗法根除HP。以24 h食管pH值监测,检测有无胃食管反流,观察在根除HP治疗前后消化性溃疡患者出现胃食管反流情况。结果根除HP与治疗前胃食管反流发生率对比差异有统计学意义(P<0.05),是否根除HP胃食管反流发生率经χ2检验,差异有统计学意义(P<0.01)。结论消化性溃疡患者在根除HP治疗后患胃食管反流病风险增加。
Objective To observe the effect of HP (eradication of Helicobacter pylori) on gastroesophageal reflux in patients with peptic ulcer. Methods Totally 86 patients were examined for HP infection by rapid urease 1,3 C breath test. Classic triple therapy to eradicate HP. 24 h esophageal pH value monitoring, detection of gastroesophageal reflux to observe the eradication of peptic ulcer patients before and after treatment of gastroesophageal reflux. Results There was significant difference between the eradication of HP and the incidence of gastroesophageal reflux before treatment (P <0.05). The incidence of eradication of HP gastroesophageal reflux by χ2 test was significantly different (P <0.01). Conclusions Peptic ulcer patients have an increased risk of gastroesophageal reflux disease after eradication of HP.