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在美国目前仍使用预防性络合剂来控制职业性铅中毒。本文对此可能造成的健康危害问题进行了讨论。络合剂对人体铅排泄量的影响:反复应用络合剂治疗后,多数病例能增加尿铅的排泄,但并不一定能降低血铅含量。例如,有人给12个蓄电池工人口服EDTA60mg/kg/天,每周服5天,连续2～3周,治疗第一周后平均血铅含量降低10μg/100ml,第三周末血铅平均含量又降低了10μg/100ml,但其中有3人的血铅含量与开始治疗时相比反而升高。有人给3名职业性铅中毒患者口服和静脉注射CaNa_2-EDTA(治疗期间脱离职业接触),在口服给药时尿、粪排铅量均见升高,在
Preventive chelating agents are still used in the United States to control occupational lead poisoning. This article discusses possible health hazards. Effect of complexing agent on human lead excretion: After repeated application of complexing agent, excretion of urinary lead can be increased in most cases, but blood lead level may not be reduced. For example, 12 battery workers orally EDTA60mg / kg / day orally 5 days a week for 2 to 3 weeks after the first week of treatment average blood lead levels decreased 10μg / 100ml, the third weekend the average level of blood lead and then decreased 10μg / 100ml, but three of them had elevated levels of blood lead instead of the initial treatment. Some people give three occupational lead poisoning patients oral and intravenous CaNa_2-EDTA (out of occupation during treatment), when oral administration of urine, excretion of lead were increased, in