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目的探讨胞二磷胆碱联合神经节苷脂治疗新生儿缺氧缺血性脑病神经行为的效果。方法 40例新生儿缺氧缺血性脑病患儿作为研究对象,随机分为实验组和对照组,每组20例。对照组采用神经节苷脂治疗,实验组在对照组基础上加用胞二磷胆碱治疗,比较两组患儿原始反射、一般状态、新生儿神经行为评分(NBNA)改善情况和临床治疗效果。结果对照组总有效率显著低于实验组,差异有统计学意义(P<0.05)。经过治疗后实验组患儿原始反射、一般状态和NBNA评分均高于对照组,差异有统计学意义(P<0.05)。结论新生儿缺氧缺血性脑病的治疗中,与单用神经节苷脂相比,加用胞二磷胆碱后的治疗效果更佳,对神经行为的改善作用更为显著。
Objective To investigate the neurobehavioral effects of citicoline combined with ganglioside on neonatal hypoxic-ischemic encephalopathy. Methods 40 neonates with hypoxic-ischemic encephalopathy were randomly divided into experimental group and control group, with 20 cases in each group. The control group was treated with ganglioside. The experimental group was treated with citicoline on the basis of the control group. The initial reflex, general status, neonatal neurobehavioral score (NBNA) and the clinical effect of the two groups were compared . Results The total effective rate of the control group was significantly lower than the experimental group, the difference was statistically significant (P <0.05). The initial reflex, general state and NBNA score of experimental group were higher than that of control group after treatment, the difference was statistically significant (P <0.05). Conclusions In the treatment of neonatal hypoxic-ischemic encephalopathy, the treatment with citicoline is more effective than ganglioside alone and the neurological behavior is more pronounced.