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金霉素点眼剂的配制方法及其稳定性,杂誌上均已有詳細的介紹。从文献上看,金霉素眼药含量与配制时攪拌、过濾时間的長短以及保存溫度均有很大的关系。最近日本眼科学会杂誌报导在金霉素眼药中每10毫升加抗坏血酸50—100mg可以防止失效,一般可持續七天之久,且对pH無影响。据說这是由于抗坏血酸的还原作用防止了金霉素的氧化作用。我們按照它所介紹的量加入抗坏血酸,結果患者滴眼后反映局部刺激性較大,使我們考虑列,抗坏血酸的加入影响了眼药的pH,于是就金霉素点眼剂加还原剂及不加还原剂的溶液进行了酸硷度及其稳定性的测定。
Chlortetracycline eye drops preparation methods and stability, the magazine has been described in detail. From the literature, chlortetracycline ophthalmic content and preparation of mixing, the length of the filter time and storage temperature have a great relationship. Recent Journal of Ophthalmology in Japan reported in the chlortetracycline eye drops per 10 ml of ascorbic acid 50-100mg can prevent failure, generally lasts for seven days, and has no effect on the pH. It is said that this is due to the reduction of ascorbic acid to prevent the oxidation of chlortetracycline. We added ascorbic acid according to the amount it introduced, the results of patients after the eye drops reflect the local irritation, so that we consider the column, the addition of ascorbic acid affects the ophthalmic pH, so on the chlortetracycline plus eye drops and reducing agent added The solution of the reducing agent was tested for its pH and its stability.