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目的探讨阿伐他汀联合缬沙坦和依那普利治疗高血压肾病的临床效果。方法选择2013年5月至2015年1月的高血压肾病患者120例作为研究对象,将所有患者随机分为治疗组与对照组,每组各60例,对照组应用缬沙坦和依那普利治疗,治疗组应用阿托伐他汀联合缬沙坦和依那普利治疗,对比两组患者的临床效果。结果治疗组患者的BUN、Scr、24 h尿蛋白、TC、LDL-C、CRP、IL-6以及TNF-α水平显著低于对照组(P<0.05)。结论高血压肾病应用阿托伐他汀联合缬沙坦和依那普利治疗具有显著临床效果,具有明显抗炎、降脂以及保护肾功能的作用,值得在临床上大力推广应用。
Objective To investigate the clinical effects of atorvastatin combined with valsartan and enalapril in the treatment of hypertensive nephropathy. Methods A total of 120 patients with hypertensive nephropathy from May 2013 to January 2015 were selected as study subjects. All patients were randomly divided into treatment group and control group, 60 cases in each group. The control group was given valsartan and enalapril Lee treatment, the treatment group with atorvastatin combined valsartan and enalapril treatment, the clinical effect of two groups of patients were compared. Results The levels of BUN, Scr, 24h urinary protein, TC, LDL-C, CRP, IL-6 and TNF-α in the treatment group were significantly lower than those in the control group (P <0.05). Conclusion Atorvastatin combined with valsartan and enalapril in hypertensive nephropathy has significant clinical effect, obvious anti-inflammatory, lipid-lowering and renal function protection. It is worth to be widely applied clinically.