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目的:了解小剂量红霉素对重症肺炎患儿胃食管反流(GER)的影响。方法:选择重症肺炎患儿25例,于鼻饲前1 h和餐后3 h连续进行食管pH监测,再给予3～5 mg/kg红霉素持续静脉滴注,同样于鼻饲前1 h和餐后3 h进行食管pH监测,比较红霉素用药前后各项反流指标的差异。结果:滴注红霉素前,重症肺炎儿童GER发生率为60.0%(15/25),滴注红霉素后,GER发生率为32.0%(8/25),用药前后比较差异有统计学意义(χ2=3.95,P<0.05)。滴注红霉素前后各项反流指标比较差异均有统计学意义(P均<0.05)。结论:重症肺炎患儿GER发病率高,小剂量红霉素静脉滴注可明显减少GER的发生。
Objective: To investigate the effect of low dose erythromycin on gastroesophageal reflux (GER) in children with severe pneumonia. Methods: Twenty-five children with severe pneumonia were selected. The esophageal pH was monitored continuously 1 h before and 3 h after meal, followed by continuous intravenous infusion of erythromycin 3 to 5 mg / kg for 1 h before nasal feeding After 3 h esophageal pH monitoring, comparison of erythromycin before and after treatment of the various indicators of reflux. Results: Before infusing erythromycin, the incidence of GER was 60.0% (15/25) in children with severe pneumonia, and the incidence of GER was 32.0% (8/25) after erythromycin instillation. The difference was statistically significant Significance (χ2 = 3.95, P <0.05). Before and after instillation of erythromycin various reflux indicators were statistically significant (P all <0.05). Conclusion: The incidence of GER in children with severe pneumonia is high. Intravenous injection of erythromycin in low dose can significantly reduce the incidence of GER.