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目的探讨脱氧核苷酸钠防治环磷酰胺(CTX)治疗难治性肾病(INS)所致不良反应临床疗效。方法治疗组与对照组均符合INS的诊断标准,常规用药相同,治疗组加用脱氧核苷酸钠静脉滴注,每天1次,连续3周。结果治疗组治疗后,患者临床症状和各脏器功能明显改善,综合各项疗效情况显示,治疗组优于对照组。结论脱氧核苷酸钠对防治(CTX)治疗(INS)所致不良反应疗效确切,可显著改善不良反应的临床症状和各脏器功能,值得临床推广应用。
Objective To investigate the clinical effects of deoxynucleoside sodium in preventing and treating adverse reactions caused by cyclophosphamide (CTX) in patients with refractory nephropathy (INS). Methods Both the treatment group and the control group were in accordance with the diagnostic criteria of INS. The conventional treatment was the same. The treatment group was treated with intravenous drip of deoxynucleate once daily for 3 weeks. Results After treatment in the treatment group, the clinical symptoms and the function of each organ were significantly improved. The comprehensive treatment results showed that the treatment group was superior to the control group. Conclusion Sodium deoxyribonucleotide has definite curative effect on side effects caused by prevention and treatment (CT), which can significantly improve the clinical symptoms and organ function of adverse reactions and is worthy of clinical application.