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通过化学转化阐明天然产物的结构早已不是一个陌生的方法。P.Karrer(1933)曾试图弄清 Spartein(1)的母核结构:
It is no longer a strange way to elucidate the structure of natural products by chemical transformation. P. Karrer (1933) tried to understand the nuclear structure of Spartein (1):