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在英国伦敦举行的“脂质体在医学上的应用”专题讨论会上,脂质体研究者报告他们的最新研究成果和脂质体用于治疗的进展情况。许多研究者讨论了由Brenda E Ryman博士开创的在体内将酶递送至细胞的研究工作。二十多年前,A Bangham(英国剑桥农业研究委员会试验室)发现双层脂质体在水溶液中形成密封的同心圆的壳,他称此为脂质体。当脂质体形成时,它在壳内隔离了一部分溶液;溶质逸出,必须通过一层或多层脂质层。它的作用在于使许多水溶性的物质分子不能迅速和容易的逸出。脂质体的这些性质引起了许多生物学家的注意。引起他们兴趣的是可能将酶捕获在脂质体中,希望它们成为溶酶体的潜在场
At the Symposium on the Medical Use of Liposomes in London, UK, liposomal researchers reported on their latest research and the progress of liposomes for treatment. Many investigators have discussed the in vivo study of delivering enzymes to cells by Dr. Brenda E Ryman. Twenty years ago, A Bangham (Cambridge, England Agricultural Research Council Laboratory) found that bilayer liposomes form a sealed, concentric shell in aqueous solution, which he calls liposomes. When a liposome is formed, it isolates a portion of the solution within the shell; the solute escapes and must pass through one or more lipid layers. Its role is that many water-soluble substances molecules can not quickly and easily escape. These properties of liposomes attract the attention of many biologists. It is of interest to them that it is possible to trap enzymes in the liposomes, in the hope that they will become potential sites of lysosomes