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骨髓移植(BMT)后的腺病毒感染有很高的发病率和死亡率。作者对1990年11月至1994年12月215次BMT中的腺病毒感染进行了回顾性分析。 病人和方法 215次儿童BMT包括血液系统恶性肿瘤(n=150),实体瘤(n=40)和其他非肿瘤性疾病(n=21)。自体BMT的急性白血病患者用环磷酰胺(200mg/kg)和马利兰(16mg/kg)作预处理方案;同种异基因BMT的血液系统恶性肿瘤预处理方案为TBI和化疗(阿糖胞苷18g/m~2和环磷酰胺90mg/kg)。非肿瘤性疾病同种异基因BMT患者未接受TBI。
Adenovirus infections following bone marrow transplantation (BMT) have a high morbidity and mortality. The authors retrospectively analyzed 215 adenovirus infections in BMT from November 1990 to December 1994. Patients and Methods 215 children with BMT included hematologic malignancies (n = 150), solid tumors (n = 40) and other non-neoplastic diseases (n = 21). Patients with acute leukemia with autologous BMT were treated with cyclophosphamide (200 mg / kg) and melitrin (16 mg / kg) as a pre- treatment regimen; allogeneic BMT hematological malignancies were pretreated with TBI and chemotherapy (cytarabine 18 g / m ~ 2 and cyclophosphamide 90 mg / kg). Non-neoplastic disease Allogeneic BMT patients did not receive TBI.