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目的：探讨胰管结石的诊断与治疗经验。方法对新乡医学：第一附属医：2000~2012年间收治的32例胰管结石患者的临床资料进行回顾性分析。结果32例胰管结石均与慢性胰腺炎合并存在，其中手术治疗组20例，内镜治疗组12例。手术组和内镜组中分别有95%和58.3%的患者腹痛完全缓解，两组在腹泻和体重减轻等症状的改善方面无显著差异。手术组术后无并发症发生，内镜组1例患者术后15个月死于胰腺癌。结论胰管结石的诊断主要通过综合应用各种影像学检查手段，外科手术和内镜治疗都可以缓解胰管结石的症状，而手术是达到根治性治疗的主要方法。“,”Objective To summarize the experience with diagnosis and therapy of pancreatic duct stones. Methods The clinical data of 32 cases with pancreatic duct stones treated in our hospital from 2001 to 2013 were retrospectively analyzed. Results Thirtytwo of the 32 cases had chronic pancreatitis. They were divided into surgery group for 20 cases and endoscopic group for 12 cases. Surgery group and Endoscopic group were 95%and 58.3%of complete remission in patients with abdominal pain, and there were no significant dif erences in the diarrhea and weight loss and other symptoms. No complications occur ed in surgery group,one patient died of pancreatic cancer in endoscopic group after 15 months later.Conclusion The diagnosis of pancreatic duct stones relies on the comprehensive application of al kinds of imaging examinations, surgery and endoscopic therapy can relieve symptoms of pancreatolithiasis. Surgery is the main way to achieve radical treatment of pancreatolithiasis.