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曾记述蛋白尿的患者有凝血酶Ⅲ的缺乏,认为因肾小球泄漏所致。提出在这些患者中此种缺乏在静脉血栓形成倾向的病因学中是重要的,主要的纤维蛋白溶酶抑制剂α_2抗纤维蛋白溶酶的分子量为65-70×10~3,预想也可能通过损伤的肾小球而漏出。作者为此测定了20例肾病综合征患者血浆中的α_2抗纤维蛋白溶酶的含量。对中至重度肾小球性蛋白尿,并经肾活检证实的20例患者及9例正常对照组用免疫电泳法检测血浆中
Patients who have documented proteinuria have a lack of thrombin III, which is thought to be due to glomerular leakage. It is suggested that such deficiency in these patients is important in the etiology of venous thromboembolism. The major plasmin inhibitor, α 2 antiplasmin, has a molecular weight of 65-70 × 10 -3, and is expected to pass Glomerular damage and leakage. To this end, the authors determined the plasma levels of α_2 anti-fibrinolysin in 20 patients with nephrotic syndrome. Twenty patients with moderate to severe glomerular proteinuria confirmed by renal biopsy and 9 normal controls were examined by immuno-electrophoresis in plasma