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微小RNAs(microRNAs,miRNAs)是一类内源性17～25个核苷酸大小的非编码RNA分子,精确调节神经元及其他细胞的发育、分化、增殖、凋亡以及参与免疫调控、神经元可塑性及信号传导过程中miRNAs转录后处理重抑制效应而增加基因表达。研究表明,miRNAs参与生命过程中一系列的重要进程,胎儿发育和妊娠病理结局受到不连续的差异性表达miRNAs的调控。miRNAs的表达水平变化与胎儿生长受限、胎膜早破、子痫前期和巨大儿等妊娠病理结局密切相关。
MicroRNAs (miRNAs) are endogenous, non-coding RNA molecules ranging in size from 17 to 25 nucleotides that precisely regulate the development, differentiation, proliferation, apoptosis and involvement of neurons and other cells in the regulation of neurons Plasticity and signal transduction miRNAs post-transcriptional repression effect and increase gene expression. Studies have shown that miRNAs are involved in a series of important processes in the life process. Fetal development and the outcome of pregnancy pathology are regulated by discretely differentially expressed miRNAs. Changes in the expression of miRNAs and fetal growth restriction, premature rupture of membranes, preeclampsia and macrosomia and other pregnancy pathological outcomes are closely related.