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近几年来由于免疫荧光技术和电子显微镜的应用,已明确肾小球疾病大多数系通过免疫机制发病。一般分为抗肾抗体型和免疫复合物型两类,前者是由于机体内出现了能和自身肾小球基底膜(GBM)抗原发生免疫反应的特异性抗体,后者是指在循环中形成的免疫复台物(抗原抗体复合物)在肾小球内沉积引起免疫损害。近年又提出了原位(In situ)免疫复合物型,此型强调循环内无免疫复合物,而是先有非
In recent years due to the application of immunofluorescence technology and electron microscopy, it has been clear that the majority of glomerular diseases are caused by the immune mechanism. Generally divided into two types of anti-renal antibody and immune complexes, the former is due to the emergence of the body and its own glomerular basement membrane (GBM) antigens antigen-specific antibodies, which refers to the formation of circulating The immune complex (antigen-antibody complex) deposition in the glomeruli caused immune damage. In recent years, put forward in situ (In situ) immune complex type, this type emphasizes no immune complex within the cycle, but the first non