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糖尿病是由遗传和环境因素共同作用而引起的一组以慢性高血糖为主要特征的临床综合征,它的危害不仅在于以糖代谢为主的一系列代谢紊乱,还包括长期高血糖所引起的糖尿病血管病变(累及冠心病、脑血管疾病、周围血管疾病、肾病、神经病变及视网膜病变等)。内皮祖细胞(endothelialprogenitorcells,EPCs)是内皮细胞的前体细胞,它参与成人新生血管的形成。糖尿病血管病变与糖尿病患者EPCs的数量减少、功能受损密切相关。在糖尿病中,高糖是影响EPCs数量和功能的重要因素,它对EPCs的影响及相关机制已成为研究者关注的热点。
Diabetes is a combination of genetic and environmental factors caused by a group of chronic hyperglycemia as the main clinical syndrome, its harm not only in a series of metabolic disorders mainly glucose metabolism, but also caused by long-term high blood sugar Diabetic vascular disease (involving coronary heart disease, cerebrovascular disease, peripheral vascular disease, nephropathy, neuropathy and retinopathy, etc.). Endothelial progenitor cells (EPCs) are the precursors of endothelial cells, which are involved in the formation of adult neovascularization. Diabetic vascular disease is associated with a reduced number of EPCs and impaired function in diabetic patients. In diabetes, high glucose is an important factor affecting the number and function of EPCs, and its impact on EPCs and related mechanisms has become a hot spot for researchers.