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目的观察微生态调节剂干预新生儿高未结合胆红素血症的疗效。方法将35例高未结合胆红素血症新生儿随机分为两组,即观察组21例、对照组14例,治疗前两组患儿临床资料及血清总胆红素值均无显著差异。两组患儿予常规治疗和原发病治疗,观察组加用丽珠肠乐胶囊1/2粒,8h1次,治疗期间每日定时查经皮胆红素值2次,治疗结束查血清总胆红素。结果观察组日均胆红素下降值为49.35±7.32μmol/L,治疗结束后血清总胆红素值为77.43±14.33μmol/L;对照组日均胆红素下降值为34.47±7.06μmol/L,治疗结束后血清总胆红素为104.54±21.72μmol/L,两组间有非常显著差异(P<0.01);观察组平均治疗天数为4.7±2.6天,与对照组平均治疗天数(7.2±3.8天)有显著差异(P<0.05)。结论丽珠肠乐干预新生儿高胆,疗效确切,提示补充双歧杆菌也可促进新生儿高胆的消退,值得临床推广运用。
Objective To observe the effect of microecological regulator on neonatal un-combined hyperbilirubinemia. Methods Thirty-five neonates with high unbound bilirubin were randomly divided into two groups: observation group (21 cases) and control group (14 cases). There was no significant difference in clinical data and serum total bilirubin between the two groups before treatment . Two groups of children to conventional treatment and treatment of primary disease, the observation group plus Cabernet lelese capsules 1/2, 8h1 times, during treatment regularly check the value of percutaneous bilirubin 2 times, the end of treatment to check serum total Bilirubin. Results The decrease of daily average bilirubin in observation group was 49.35 ± 7.32μmol / L, the total serum bilirubin was 77.43 ± 14.33μmol / L after treatment, and the decrease of daily average bilirubin in control group was 34.47 ± 7.06μmol / L, the total serum bilirubin after treatment was 104.54 ± 21.72μmol / L, there was a significant difference between the two groups (P <0.01); the average treatment days in the observation group was 4.7 ± 2.6 days, ± 3.8 days) were significantly different (P <0.05). Conclusion Lizhuchangleng intervention in neonatal high gall, curative effect is exact, suggesting that supplementation of bifidobacteria can also promote neonatal hypercholesteremia, worthy of clinical promotion and use.