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目的:探讨亚临床妊娠期肝内胆汁淤积症(ICP)对围生结局的影响。方法:选择152例孕期有皮肤瘙痒、而肝功能和胆汁酸正常的亚临床ICP孕妇为研究组,对照组为152例无皮肤瘙痒、年龄和产次匹配的正常产妇,比较两组的围生结局。结果:研究组的产后出血发生率、羊水Ⅱ°～Ⅲ°污染发生率和产时胎监异常发生率分别为11.18%、20.39%和15.13%,明显高于对照组的1.98%、7.89%和4.61%(P<0.05)。两组的孕周、剖宫产率、阴道助产率、早产发生率和新生儿窒息发生率差异无统计学意义(P>0.05)。两组均无死胎、死产和新生儿死亡发生。结论:皮肤瘙痒、而肝功能和胆汁酸正常的亚临床ICP对产妇和新生儿的围生结局有一定程度的影响,临床上应提高警惕。
Objective: To investigate the effect of subclinical intrahepatic cholestasis (ICP) on perinatal outcome. Methods: 152 pregnant women with pruritus and subclinical ICP with normal liver function and bile acid were selected as the study group. The control group consisted of 152 normal pregnant women without skin pruritus, age and birth-parity. The peri- ending. Results: The incidence of postpartum hemorrhage, incidence of amniotic fluid Ⅱ ° ~ Ⅲ ° amniocentesis and birth abnormalities during labor were 11.18%, 20.39% and 15.13%, respectively, which were significantly higher than those of the control group (1.98%, 7.89% and 4.61% (P <0.05). There was no significant difference in gestational age, cesarean section rate, vaginal delivery rate, preterm birth rate and neonatal asphyxia between the two groups (P> 0.05). No fetal deaths occurred in both groups, with stillbirth and neonatal deaths occurring. CONCLUSIONS: Itchy skin, and subclinical ICP with normal liver function and bile acid, have a certain degree of effect on the perinatal outcome of the mothers and newborns, and should be vigilant clinically.