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按照ADA标准选择 59个符合要求的 2型糖尿病核心家系 ,进行问卷调查、OGTT试验、测胰岛素、C肽、血脂。将所获得资料汇成系谱图。结果 :①男女之比为 1 :1 58(P <0 0 1 ) ;②母亲患病人数显著高于父亲( 32 2 %对 1 3 6% ,P <0 91 ) ;③同胞对中 4 7%人是患者 ;④患糖尿病的父母亲中子女的糖尿病患病串无明显差异( 43 7%对 4 6 9%P >0 0 5)。结论 :糖尿病具有明显的遗传倾向 ,家族性 2型糖尿病遗传方式似不支持多基因遗传 ,母亲患者在遗传学上具有重要作用
Fifty-nine eligible type 2 diabetic core families were selected according to ADA criteria, and questionnaires, OGTT tests, insulin, C-peptide, and lipids were performed. The data obtained are compiled into pedigree. Results: ① The ratio of male to female was 1: 1 58 (P <0.01). ②The prevalence of maternal illness was significantly higher than that of the father (32.2% vs 136.6%, P <0 91) % Of the patients were patients; ④ There was no significant difference in the prevalence of diabetes among the parents of children with diabetes (43.7% vs 46.9% P> 0.05). CONCLUSIONS: Diabetes has a significant genetic predisposition, and familial type 2 diabetes does not appear to support polygenic inheritance, with maternal genetics playing an important role