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目的提高对原发性膀胱印戒细胞癌(primary bladder signet-ring cell carcinoma,PBSRCC)的诊疗认识。方法通过对2例原发性膀胱印戒细胞癌临床病例资料的分析,并结合文献进行复习讨论。结果术前2例患者行B超、脱落细胞、CTU、膀胱镜等检查明确为膀胱占位。行膀胱全切术手术治疗后,病理结果显示为膀胱印戒细胞癌,并行相关检查排除转移性肿瘤。1例予以GC方案化疗,4周后行自体细胞免疫回输(CIK)治疗,术后6个月死于广泛转移。另1例未行化疗,随访至今2个月无复发及转移。结论原发性膀胱印戒细胞癌较罕见,主要依靠影像学检查发现,临床确诊主要依靠病理检测。手术治疗是最主要的治疗方法,辅助化学治疗药物的作用及疗效还有待继续临床研究。
Objective To improve the diagnosis and treatment of primary bladder signet-ring cell carcinoma (PBSRCC). Methods Based on the analysis of 2 cases of primary bladder signet ring cell carcinoma clinical data, and review the literature review. Results Preoperative 2 patients underwent B ultrasound, exfoliated cells, CTU, cystoscopy and other tests clear for the bladder space. Surgical treatment of bladder total hysterectomy, the pathological findings showed signet ring cell carcinoma of the bladder, parallel examination to exclude metastatic tumors. One patient underwent chemotherapy with GC regimen. After 4 weeks, he received autologous immunosuppression (CIK) and died of extensive metastasis 6 months after operation. Another case of no chemotherapy, follow-up 2 months without recurrence and metastasis. Conclusion Primary bladder signet ring cell carcinoma is rare, mainly based on imaging findings, clinical diagnosis mainly depends on pathological examination. Surgical treatment is the most important treatment, the role of adjuvant chemotherapy drugs and efficacy remains to be clinical studies.