,New players in non-alcoholic fatty liver disease induced carcinogenesis: lipid dysregulation impair

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Hepatocellular carcinoma (HCC), the primary cancer of the liver, is the fifth most common cancer and the second most common cause of cancer-related death worldwide with an expectancy to increase its incidence over the next 10–20 years (1). Although chronic viral infections [i.e., hepatitis B or C virus (HBV, HCV)], and chronic exposition to hepatotoxic factors such as toxins and alcohol are a major cause of HCC (2), in weste countries and especially in the USA, obesity and dysregulated lipid metabolism are emerging as important non-viral factors associated with HCC (3,4).
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